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Treatments with any of the multi-agonists significantly reduced body weight from 24- to 72-h relative to control PWA animals, while GLP1 decreased body weight only from 24- to 48-h

In addition, GRADE assessment, sensitivity tests, and subgroup analysis were used to assess quality of studies, detect publication bias and identify potential sources of heterogeneity among trials, respectively

These cost factors significantly influence market pricing dynamics, prompting manufacturers to invest in research and development to identify more cost-effective production alternatives

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