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La participacin de la prdida de peso en los efectos del tratamiento con LIRA en el programa SCALE es variable, encontrndose en torno al 100% en resultados sobre fracciones lipdicas, presin arterial e ndice apnea-hipopnea y alrededor del 30% en los efectos sobre el metabolismo hidrocarbonado, en probable relacin con el efecto incretnico del frmaco20

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These drugs slow gastric emptying and alter bile composition, which could contribute to gallstone formation

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