semaglutide if not overweight GLP-1 agonists and changes in body mass and composition in adults with or obesity with or without type 2 diabetes mellitus: a systematic review and meta-analysis Semaglutide for Weight Loss: A

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Alternating increases risk of severe nausea, vomiting, dehydration, and GI upset due to dose overlap and disrupted titration

M.IannantuoniF.Escribano-LpezI.Lpez-DomnechS.et al (2019)

In a trial of adult patients with type 2 diabetes and BMI greater than or equal to 27 kg/m2 for weight reduction (Study 3), diabetic retinopathy was reported by 4% of WEGOVY injection-treated patients and 2.7% placebo-treated patients [see Clinical Studies (14.2)]