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This is because the deeper fascial layer, including the SMAS layer, also plays a critical role in facial support and contour

10.1093/jnci/djt123 108 WolpinB

At 12 months, the on-medication MDS-UPDRS Part III score was 14.9 in the lixisenatide group versus 18.8 in the placebo group, a between-group difference of 3.08 points (P = 0.007) [3]