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Pharmacokinetics in the rat after single oral administration

Together with its role in glutamate excitotoxity, NO could contribute to oxidative stress mechanisms in the pathogenesis of PD by interacting with ferritin to release iron, inducing mitochondrial complex I damage (Molina et al., 1998), and by inducing nitrosylation of proteins (Fernndez et al., 2013)

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As with any therapeutic agents, the potential for side effects associated with suppression of GH should be considered