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All four D50 codes are active for services October 1, 2025 through September 30, 2026 under the FY2026 ICD-10-CM April 1, 2026 release

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doi: 10.1146/annurev.physiol.010908.163145 36

This is one major reason why MCAS-like symptoms so often emerge or escalate in the late thirties and early forties, even before periods become noticeably irregular