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The System: An HPLC system consists of a solvent reservoir, a high-pressure pump, an injector, a column, and a detector

Monocytes are circulating cells that once recruited to the TME can differentiate into DC, MDSC or macrophages (93), depending on the cytokine and growth factor signature of the TME (9497)

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These environmental factors are not confined to specific regions but are omnipresent, with notable occurrences observed in South Asia and Central America, as evidenced by studies conducted in Nicaragua, El Salvador, India, and Sri Lanka [41, 42]