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Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

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The continuous supply of progenitor and new epithelial cells physically promotes the transit of the latter from the crypts up to the villus tip, where they populate the newly vacant area of previously shed apoptotic epithelial cells (Gehart and Clevers, 2019)