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For this purpose, RNA sequencing data from the CGGA database were evaluated with the CIBERSORT computational tool, which estimates the proportions of 22 immune cell subtypes infiltrating the tumor microenvironment based on gene expression data

Furthermore, interaction of S100A12 with TLR4 activates TLR4 signaling pathway ( Figure 3 ), resulting in enhanced inflammatory response and migration of monocytes (153)

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In addition, results from post mortem brain imaging studies have shown variations in brain levels of dopamine, glutamate, GABA, serotonin, and acetylcholine (17)