august 24 2025 glp-1 drugs have taken the world by storm, helping many people lose 11%–16% of their body weight. But a new Cochrane review reveals something surprising: the evidence supporting these blockbuster injections isn't How Supply and Demand for

Current evidence suggests that a 20% increase in Firmicutes , accompanied by a proportional decrease in Bacteroidetes , may be associated with an estimated increase of approximately 150 kcal in daily energy harvest, potentially facilitating long-term weight gain (75)

This triple mechanism explains why people taking GLP-1 therapy typically experience sustained appetite suppression and gradual, consistent weight loss over months

If you were prescribed Ozempic and want to switch to a different medication, talk to your provider

This cycle may contribute to continued blood-vessel irritation and plaque progression

doi:10.3389/fendo.2020.00478 157