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( a ) A Ligplot+ v2.2 diagram of the N-terminal interacting residues of Ex-4-D-Ala bound to GLP-1R as observed in the conformer 1 model

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Focal positive staining is noted around some intra-tumoural blood vessels for S100 and CD34

Unlike earlier medications like semaglutide (Ozempic) and tirzepatide (Mounjaro), retatrutide is designed to act on multiple hormone receptors simultaneouslyincluding GLP-1, GIP, and glucagon receptors

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