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Similarly, an association was observed between GLP-1 RAs use and a lower risk of MAKEs, although it was less pronounced in patients with proteinuria and those receiving short-acting GLP-1 RAs

This aspect highlights the need for careful interpretation of experimental findings, particularly when activity is reported ( Weight of evidence: Overall evidence is Low given potential assay-interference and PK constraints

Heart failure: promotes sodium and water excretion, reducing cardiac workload, and lowering risk of hospitalization and cardiovascular death

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