Ras leads to the activation of different mitogen-activated protein kinase (MAPK) cascades, including extracellular-signal-regulated kinase (ERK), p38 MAPK , and c-Jun N-terminal protein kinase (JNK) (Graziani et al., 1993)
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Common side effects The most frequently reported side effects are mild and transient: Dizziness (most common, usually related to injection speed) Headache (typically resolves within 24 hours) Skin flushing (related to vasodilation effects) Nausea (more common at higher doses) Fatigue or insomnia (varies by individual) Agitation or anxiety (infrequent) Weight loss (reported in some longer-term studies) Feeling hot (transient, related to administration) Most of these side effects correlate with administration speed rather than the compound itself
Statements Author contributions HZ: Conceptualization, Supervision, Visualization, Writingoriginal draft, Writingreview and editing