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In the case of cirrhosis, PPAR can reduce portal pressure glucose and lipoprotein metabolism and insulin resistance in skeletal muscle

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Baig et al

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They showed that semaglutide enhanced histological parameters of fibrosis and inflammation while decreasing hepatic expression of genes associated with fibrotic and inflammatory cascade: through proteomic profiling of serum from MASH patients treated with semaglutide, they detected 72 proteins linked to disease resolution and validated these findings in preclinical mouse models and an independent patient cohort [28]