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Further, recent studies suggest that some CNS macrophage populations are derived from the skull and vertebral bone marrow, and these populations occupy unique niches within the CNS (Cugurra et al., 2021)

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Despite some controversies, such as drug concentration and timing, inconsistent conclusions due to different definitional parameters, and insufficient research on the mechanism of influence, these findings can help clinicians choose the most appropriate treatment plan and clinical follow-up