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Nonfatal stroke risk was decreased by 16% and hospitalization for heart failure by 10%

Microglia and astrocyte activation causes an increase in cytokines, which in turn activates the NF-B pathway and causes oxidative damage to proteins

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In DCCT, participants were randomised to either intensive or conventional insulin therapy (achieving a median HbA 1c level of 7% vs 9% [53 vs 75 mmol/mol], respectively) and followed for a mean of 6.5 years