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The age-related decline in neuromodulator levels, combined with the less-significant learning and memory effects from PXN LOW in aged animals (though a trend was noted, P = 0.07), may explain the reduced cognitive benefits of both caffeine and paraxanthine in older individuals

As a reminder, agonists attempt to mimic the molecules action, while antagonists attempt to block the molecules action

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When activated, it drives the production of TNF-alpha, IL-1beta, IL-6, COX-2, and hundreds of other pro-inflammatory mediators

The impact of GLP-1 RAs on bone health has been explored in multiple clinical studies, though findings are inconsistent