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In contrast, a dysbiotic microbial configuration characterized by reduced BSH functional potential may contribute to a less efficient microbial transformation of bile acids, potentially influencing the composition of the host bile acid pool and its downstream signaling through FXR and TGR5 pathways

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Expert Opinion on Drug Safety , 18

Reproductive Health: FOXO4-DRI shows promise in improving reproductive health by targeting senescent Leydig cells, which contribute to age-related hypogonadism and reduced fertility

Probing insulin sensitivity with metabolically competent human stem cell-derived white adipose tissue microphysiological systems