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GSH concentrations were significantly reduced in the sh-GCLC group compared to the control group, indicating impaired antioxidant capacity due to GCLC inhibition

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Alcohol 20:271276 Addolorato G, Balducci G, Capristo E et al (1999) Gamma-hydroxybutyric acid (GHB) in the treatment of alcohol withdrawal syndrome: a randomized comparative study versus benzodiazepine

Effectiveness: Slower onset of results compared to IV therapy due to lower bioavailability

Regarding expression and activity, the knowledge about the regulation of carriers and enzymes that modulate -oxidation in cancer cells is of extreme interest since their inhibition may significantly affect the tumorigenic potential even in the presence of compensatory metabolic pathways