Appetite changes vary by person and should be discussed with a provider if they become difficult to manage
For peptides that work systemically like growth hormone secretagogues that act on the pituitary, or repair peptides like BPC-157 that work through systemic circulation this is the only delivery method that reliably produces the expected effect
And weight gain is often driven by multiple factors: hormones, insulin resistance, medications, sleep deprivation, stress, and muscle loss
More serious but less common adverse effects include pancreatitis, gallbladder disease (cholecystitis and cholelithiasis), and acute kidney injury, particularly in the setting of severe dehydration from gastrointestinal symptoms
Peptide stacking 101: combining compounds safely