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There were a total of six double-blind placebo-controlled human clinical trials done spanning a total of ~900 clinically obese subjects between 2001 and 2006

B12 protects your brain cells in the same way it helps protect nerve cells, by protecting their myelin sheaths

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When you are giving a B12 injection subcutaneously, you pinch the fat to make sure youre only penetrating the subcutaneous tissue (or the innermost layer of skin) and pull it away from the muscle, then insert the needle

proper injection technique and site rotation can minimize these local reactions, and they tend to resolve quickly on their own