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Tissue-specific effects Despite shared machinery, tissue-specific effects emerge from which receptor is engaged where: pancreatic islets (GLP-1R + GIPR enhance insulin secretion and -cell function), central nervous system (GLP-1R + GIPR + GCGR coordinate appetite and energy-expenditure signalling), adipose tissue (GIPR + GCGR produce the distinctive fat-mobilisation profile), and liver (GCGR effects on hepatic fat metabolism relevant to fatty-liver research)