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[3] Intramuscular injection, or more specifically peri-lesional injection near an injured tendon or joint, has been used in animal models to test whether local delivery produces superior effects compared to systemic dosing

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Rather than focusing on short-term anecdotes, serious investigators try to map which pathways appear most responsive, what concentrations are relevant in their models, and how repeatable those findings are in different systems

Pharmacokinetic modeling in hepatectomy patients shows a 30 % reduction in clearance