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Description

In brief, the brain was homogenized in phosphate buffered saline (pH 8.0) using a homogenizer

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Genetic recombinant experiments were reviewed by Safety Officer in RIKEN, and approved by the director of RIKEN Wako Campus (approval number: 2022-029(1))

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It has been postulated that the restoration of insulin signaling sensitivity by GLP-1RA treatment and improved growth factor signaling, as shown by increased levels of activated ERK1 and insulin receptor substrate-1 (IRS1) following semaglutide treatment, is responsible for the normalization of stem cell proliferation and neurogenesis in the brain [93]

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