"It's relentless and it's constant", said the 50-year-old Powell River, B.C., resident
The Emotional Dimension Food has always been about more than nutrition
Articles Chronically Decerebrate Rats Demonstrate Satiation But Not Bait Shyness ( Science ) Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial ( JAMA ) Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits ( Cell ) The Biology of Human Starvation: Volume I ( University of Minnesota Press ) Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake ( Cell Metabolism ) Changes in Energy Expenditure Resulting from Altered Body Weight ( The New England Journal of Medicine ) Energy Balance After SodiumGlucose Cotransporter 2 Inhibition ( Diabetes Care ) The Origin and Understanding of the Incretin Concept ( Frontiers in Endocrinology ) The development of Byetta (exenatide) from the venom of the Gila monster as an anti-diabetic agent ( Toxicon ) Once-Weekly Semaglutide in Adults with Overweight or Obesity ( The New England Journal of Medicine ) Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes ( The New England Journal of Medicine ) LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept ( Cell Metabolism ) Cholecystokinin decreases food intake in rats ( Journal of Comparative and Physiological Psychology ) Dopamine subsystems that track internal states ( Nature ) Water and sodium intake of wild and New Zealand rabbits following angiotensin ( Peptides ) Thirstand Brain Control of Water Balance: Recent research on thirst suggests that sodium-sensitive receptors near the third ventricle participate in the control of the complex balance of fluids in the body ( American Scientist ) A gut-to-brain signal of fluid osmolarity controls thirst satiation ( Nature ) Thirst neurons anticipate the homeostatic consequences of eating and drinking ( Nature ) The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement ( Neuron ) Mind over milkshakes: Mindsets, not just nutrients, determine ghrelin response ( Health Psychology ) Huberman Lab Episodes Mentioned Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging Dr
Long-term hyperglycemia promotes renin and angiotensin II synthesis in mesangial cells, leading to elevated glomerular capillary pressure and permeability, which are key components in the development of proteinuria
So post-GLP-1, your knees may no longer be overloaded by mass, but theyre still: Tracking according to old alignment (valgus/varus habits, rotational patterns) Responding to trunk and pelvis strategies that were built around a forward-shifted center of gravity Low back & spinal curves Multiple studies now connect abdominal obesity with: Increased lumbar lordosis and altered spinal alignment Greater gravitational torque on the lumbar spine Higher likelihood of low-back pain independent of age and activity level
