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Although injectable fillers are often considered the most accessible solution for volume restoration, treating large-volume deficits with fillers alone may lead to an unnatural appearance and the so-called overfilled syndrome, characterized by impaired facial expression [91]

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Depressed liver function because of a toxic or overbur- dened liver can also influence the conversion of T4 to T3 via cytochrome P450 activity and result in low T3 levels