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10.1016/s0893-133x(01)00229-9 46 HsiehJ

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Loargys is a focused orphan launch, using accelerated approval to formalize enzyme replacement for ARG1-D, with confirmatory follow-through as the durability test

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Approved by the FDA in 2014, apremilast offers a targeted approach to managing inflammation by modulating intracellular cyclic adenosine monophosphate (cAMP) levels, thereby reducing the production of pro-inflammatory cytokines (Papp et al