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Originally developed to help regulate blood sugar for individuals with type 2 diabetes, these medications have gained recognition for their ability to support weight loss and appetite control

In obesity treatment, the trajectory is more dynamic

130,218 At the molecular level, GLP-1 activates the cAMP response element-binding protein (CREB) via its receptor (GLP-1R), a transcription factor crucial for expressing the insulin gene

Finally, we presented our insights on clinical concerns such as appropriate trial endpoints, management of comorbidities, and future developments

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