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doi:10.1016/j.stemcr.2015.04.001

Additional experimental data support the protective role of GLP-1, including improved outcomes in DPP-4 knockout rats exposed to endotoxins and reduced mortality following GLP-1R activation ( Taken together, preclinical and clinical studies have demonstrated that GLP-1 receptor agonists exert pleiotropic effects extending beyond glycemic control, influencing multiple organ systems including the nervous, respiratory, hepatic, renal, cardiovascular, reproductive, and immune systems (Figure 4)

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If these clinical trials show limited toxicity, the potential use of MC4R for ASD human research clinical trials may be a prominent step forward as a potential novel neurotherapeutic agent for the treatment of this complex disorder

One study assessed 1,403 women who had received paroxetine, other SSRIs, or other antidepressants during their first trimester