semaglutide a glp-1 New GLP-1; (Ozempic) Semaglutide Shows Secondary Cardiovascular Prevention

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The combination group included those who added a newer generation GLP-1RA (i.e., exenatide once weekly [OW], dulaglutide, semaglutide OW T2D, or oral semaglutide) or dual GLP-1/GIP agonist (tirzepatide T2D) to their SGLT2i (i.e., canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, or bexagliflozin) treatment, with persistent use of a GLP-1RA and SGLT2i for 180 days each and an overlap 120 days, where the gap after exhaustion of days supply was required to be 30 days

In the primary culture cells of high-fat diet mice, transcriptome analysis showed that the gene expression of L cells with many characteristics was impaired (Richards et al., 2016)

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The study showed that the total number of hypoglycemic episodes of oral semaglutide, subcutaneous semaglutide, and placebo was low and similar [16]