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Given the potential for mood changes, keep a journal of your emotional state and share it with your healthcare provider

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Ligand binding triggers receptor autophosphorylation and recruitment of insulin receptor substrate (IRS-1, IRS-2) and Shc adapter proteins, activating the PI3KAktmTOR and RasRafMEKERK signaling cascades

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These findings suggest that part of the clinical benefit of GLP-1RAs in PsO may derive not only from metabolic improvements but also from direct modulation of adipose-driven inflammatory pathways