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A systematic review covering topical, oral and IV glutathione concluded that although topical/oral forms show some effect, the quality of evidence is modest and the effects modest too

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[61] in 1990, and they found that orthodihydroxy or catechol groups in the B-ring, a 2,3-double bond of the C-ring, and OH substitution on positions 3 and 5 of the C-ring and A-ring, respectively, are important players in antioxidant action of quercetin [61]

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