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It has been reported that CRTC2 is highly expressed in lung cancer tissues compared to adjacent normal

In a murine model of B16F10 melanoma expressing both VEGF-C and chicken ovalbumin (OVA), overexpression of VEGF-C in cancer cells promotes lymphangiogenesis in both primary tumors and TDLNs, leads to CD8+ T cell immune tolerance via LEC cross-presentation ( Figure 1 ), protects tumors against preexisting anti-cancer immunity, and promotes the local elimination of OVA-specific CD8+ T cells (93)

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Because large publicly available datasets in American Latino ancestry are currently limited, replication was performed using the UK Biobank European ancestry GWAS as well as previously published studies identified through the GWAS Catalog 51,53,54