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But negative consequences associated with repeated use of the recombinant product resulted in the search for safer and effective alternatives

The metabolic activation leads to the activation of DNA adducts which if escapes the repair mechanism can result in miscoding and permanent mutation

The method of administration (self-injection, oral, or topical), treatment duration, and dosage level all impact the total cost

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By week 4, many of these patients have moved from significant functional impairment from GI symptoms to largely resolved or substantially reduced symptom burden