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doi: 10.3389/fphys.2025.1606267 Received 05 April 2025 Accepted 02 September 2025 Published 22 September 2025 Volume 16 - 2025 Edited by Giovanna D'Arcangelo, University of Rome Tor Vergata, Italy Reviewed by Blake Graeme Perry, Massey University, New Zealand Bruce Rogers, University of Central Florida, United States Kang Chen, Tianjin University of Sport, China Updates Copyright 2025 Allison, Bedi, Rourke, Mizzi, Walsh, Heisz and Al-Khazraji

For instance, improved metabolic health and weight loss achieved through GLP-1 receptor agonist therapy might secondarily influence neurotransmitter balance through reduced systemic inflammation or improved insulin sensitivity in the brain

Guarana, often used as a supplement for its caffeine content, poses similar considerations, as its consumption may inadvertently lead to stimulant detection beyond permissible thresholds during NCAA drug tests