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For people seeking significant weight loss or tight blood sugar control, GLP-1 medications like semaglutide offer substantially greater clinical effect than berberine supplementation alone

Additionally, leptin expression in adipose tissue was suppressed, thereby inhibiting inflammatory responses in adipocytes via multiple regulatory mechanisms [97]

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Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

doi: 10.1371/journal.pone.0070933