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439,440 Epidemiological studies have consistently shown an inverse correlation between HDL-C levels and ASCVD risk, 441,442 leading to the hypothesis that increasing HDL-C levels could reduce cardiovascular events

Preclinical research suggests neuroprotective effects, reduced inflammation, and potential benefits for cognition, but translating these findings to clinical mental health outcomes requires cautious interpretation

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Phosphorylation of Drp1 at Ser637 by Ca 2+ /calmodulin-dependent protein kinase I (CaMKI) and protein kinase A (PKA) has an opposite, inhibitory effect on mitochondrial fission [316, 317]