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This study aimed to develop a stable, rectally deliverable EGCG-based formulation to mitigate radiation-induced rectal injury
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
Mann, R., Mediati, D., Duggin, I., Harry, E
FOXO4-DRI + NAD+ Combines senescent cell removal with mitochondrial and cellular energy support
It also serves as a substrate for various antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which further amplify its protective effects
