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The most frequently reported symptoms include: Nausea (especially during dose increases) Vomiting Diarrhea Constipation Abdominal discomfort Decreased appetite (an expected effect of the medication) For most patients, side effects stay in the tolerable range and tend to taper off as treatment continues

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Furthermore, a review of the drug instructions for GLP-1 RAs revealed that only the instructions for semaglutide do not list cholecystitis and cholelithiasis as an AE or mention them in the precautions

Many of these earlier studies were based on the hypothesis that IPF is an inflammatory disorder

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