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In addition, Berberine reduces the release of inflammatory factors such as TNF- and IL-6 by inhibiting the CYP1B1 and NF-B pathways, upregulates miR-204 to target and regulate HIF1/NFATc2, inhibits the crosstalk between oxidative stress and inflammation, and suppresses abnormal cell apoptosis and fibrosis by regulating the Bax/Bcl-2 ratio and TGF-1 expression (Luo et al., 2021