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36 , 130143 e135 (2024)

Protecting Muscle and Metabolism One of the most overlooked risks of rapid weight loss is loss of lean muscle mass

2023 Ludvik B, Giorgino F, Jodar E et al (2021) Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

Be prepared for flow changes during the first few months of treatment

A rate of 1 to 2 pounds per week through a calorie deficit of about 500 to 1,000 calories per day, paired with physical activity and behavior changes, is typically recommended