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For these individuals, extra vigilance may be warranted

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announced the decision to discontinue the development of danuglipron (PF-06882961), an oral glucagon-like peptide-1 (GLP-1) receptor agonist, which was being investigated for chronic weight management

it can leave a patient lighter but in a less favourable metabolic position than before treatment began, and it is a significant contributor to the weight regain that some patients experience once pharmacological appetite suppression is reduced.4 That was the landscape as it stood