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Moreover, CICR requires continual activation of VDCCs by Ca 2+ within intracellular microdomains, but not by robust Ca 2+ influx from extracellular spaces [8,15,17,24]

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It also became evident that utilizing such combination therapy might result in a more effective strategy toward curtailing cardiometabolic risks rather than relying on individual treatments alone

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Such hyper-inflammatory state could lead to loss of appetite, altered intestinal absorption, impaired gut permeability, and malnutrition 683,684