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Sterol regulatory element-binding proteins (SREBPs), peroxisome proliferator-activated receptor-alpha (PPAR-), AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuins1 (SIRT1), and nuclear factor kappa B (NF-B), fatty acid synthase (FAS), glutathione (GSH), oxidized glutathione (GSSG), 4-hydroxynonenal (4-HNE) and malondialdehyde-acetaldehyde adducts (MAA)

567 Increased FOXP3 expression reprograms Treg metabolism by inhibiting c-Myc and glycolysis, increasing OXPHOS, and increasing NAD + oxidation, enabling Tregs to adapt to low-glucose, high-lactate TMEs, 602 thus suppressing antitumor immunity

That includes medical monitoring, nutritional counseling, support with behavior changes and realistic expectations

doi: 10.1016/j.pop.2023.03.009 4 LimWCWangYMacDonaldJKHanauerS

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