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While the clinical significance of this in healthy adults is still being characterised, the theoretical concern about sustained supraphysiological IGF-1 and long-term tissue effects is the basis for the oncogenic risk concerns flagged in the long-term safety literature

Consistent with a proposed role in Ca 2+ regulation, we observed MS4A15 localization to the ER (Supplementary Fig

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We have detected acquired melanocytic nevi without the features of abnormalities in 38 patients (9.5%), whereas only 2 patients reported them as their major concern