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However, in contrast to the healthy controls, the impedance continued to markedly rise above the initial baseline values with an increase in impedance magnitude of |Z| 74.92% 0.69, in-phase impedance (Z re ) of 301.67% 3.55, and out-of-phase impedance (Z im ) of 64.73% 0.62

It is rapidly reduced by cytosolic liver enzymes to its active metabolite, 10-monohydroxy derivative (MHD), which is an enantiometric mixture of S-liscarbazepine and R-liscarbazepine in a ratio of 4:1

These results suggest that flare triggers may be specific to certain patients, and that implementing recommendations for prevention strategies in all patients may be too restrictive

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