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Because amylin receptors are obligate heterodimers of the calcitonin receptor with RAMP1, RAMP2 or RAMP3, the system is a standard model for studying how accessory proteins reshape the ligand binding pocket of a class B1 GPCR, and cagrilintide is used to probe that question alongside selective agonists

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Vadher K, Patel H, Mody R et al (2022) Efficacy of tirzepatide 5, 10 and 15 mg versus semaglutide 2 mg in patients with type 2 diabetes: an adjusted indirect treatment comparison

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