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222,227 Signaling pathways linked to AD pathogenesis Neuroinflammatory signaling Several pathological factors in AD, such as A, pro-inflammatory cytokines, and oxidative stress, activate microglia and initiate downstream signaling pathways such as MAPK, NF-B, and PI3K/Akt

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Appropriate exercise has beneficial effects on the gut microbiota, which may involve complex stress responses and neuroenteroendocrine activation ( Bacillus phylum ratio (Wastyk et al., 2021)

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