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Consequently, vascular dysfunction, including endothelial and blood-brain barrier (BBB) impairments, can lead to reduced blood flow, depriving neurons of the necessary substrates for ATP production (260)

In summary, the results demonstrate that Dihexa is a metabolically stable and BBB-permeable AngIV analog that effectively reverses scopolamine-induced cognitive deficits and improves spatial learning in aged rats

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---------- This combination of cosmetics / OTC Drug is used for your basic skin care and gives a benefit for wrinkle care

The two Phase II failures together, in populations chosen because they might plausibly benefit, are why the program did not continue