Molecularly, ligament fibroblasts in OA upregulate MMP and inflammatory mediators, contributing to ECM degradation and mechanical instability (Table 1) (Nyland et al., 2020)
As such, the majority of citations referenced in this manuscript originate from local researchers in the DRC and other sub-Saharan African countries as this is where the current expertise related to konzo is most prevalent
Some are FDA-approved to treat obesity (Wegovy, Saxenda), while others can be used off-label for weight loss (Mounjaro, Ozempic, Rybelsus, Victoza, Trulicity)
Once reconstituted, the 4-week window begins regardless of how the powder was previously stored
A 1c levels at the end of the study were 6% vs